THE 5-SECOND TRICK FOR PKRRATING

The activated enzyme then phosphorylates its important substrate, the translational initiation element eIF2α. The ensuing translational arrest blocks viral replication. PKR belongs to the conserved family of four protein kinases (PKR, PERK, GCN2, HRI) that all phosphorylate eIF2α in reaction to distinctive stimuli12, triggering the integrated ten